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The full spectrum of neurologic symptoms, the underlying neuropathophysiology, and neurologic risk factors are poorly understood. Surgical treatment in conjunction with long-term antimicrobial treatment resulted in favorable outcomes no relapses were seen after 6 months of follow-up.īabesiosis is a globally distributed parasitic infection caused by intraerythrocytic protozoa. tularensis was initially identified in 2 patients by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry molecular methods were used for 6 patients. Although positive cultures are typically obtained in only 10% of tularemia cases, strains grew in all 8 of the patients. Among those 8 patients, clinical symptoms appeared 7 days to 19 years after the joint placement and were nonspecific to tularemia. We also reviewed relevant literature and found only 5 other cases of Francisella-related prosthetic joint infections worldwide, which we summarized. tularensis subspecies holarctica–related prosthetic joint infection that occurred in France during 2016–2019. Its most typical manifestations in humans are ulceroglandular and glandular infections in prosthetic joints are rare. Tularemia is a zoonotic infection caused by Francisella tularensis. Equitable efforts should continue to identify, treat, and prevent mpox among PEH, who often experience severe disease. Public health follow-up and contact tracing detected no secondary mpox cases among PEH in congregate shelters or encampments. Some case-patients stayed at multiple locations during the 3-week incubation period. PEH case-patients lived in shelters, encampments, cars, or on the street, or stayed briefly with friends or family (couch surfed). Sexual contact was likely the primary mode of transmission 84% of patients reported sexual contact <3 weeks before symptom onset. Hospitalization was required for 21% of case-patients because of severe disease. Seventy-one (60%) PEH mpox case-patients were living with HIV, 35 (49%) of them virally suppressed. Age and sex were similar for mpox case-patients among PEH and in the general population.

In Los Angeles County, California, USA, public health surveillance identified 118 mpox cases among persons experiencing homelessness (PEH) during July–September 2022. SARS-CoV-2 rapid testing and detection methods for big cats and other susceptible animals should be developed and validated to enable timely implementation of One Health investigations. Close contact with large cats is a risk factor for bidirectional zoonotic SARS-CoV-2 transmission that should be considered when occupational health and biosecurity practices at zoos are designed and implemented. Forward contact tracing investigation confirmed probable lion-to-human transmission. Three exposed employees subsequently had onset of symptoms, 2 with viral genomes identical to the lion’s.

Traceback investigation narrowed the source of infection to 1 of 6 persons. Zoo employees were screened, monitored prospectively for onset of symptoms, then rescreened as indicated results were confirmed by using reverse transcription PCR and whole-genome virus sequencing when possible. A vaccinated African lion with physical limitations requiring hand feeding tested positive for SARS-CoV-2 after onset of respiratory signs. We describe animal-to-human transmission of SARS-CoV-2 in a zoo setting in Indiana, USA. Although the infection serves as the initial trigger, sequelae after antibiotic therapy are associated with unremitting systemic IFN-α levels, consistent with the pathogenic role of this cytokine in interferonopathies in other conditions. Highest IFN-α levels corresponded with severe disease. In contrast, subjective symptoms that persisted after use of antibiotics were associated with increased levels of serum interferon-α (IFN-α), which were already observed at study entry, and remained increased at each subsequent timepoint. Those responses resolved with antibiotic therapy, and associations between CSF cytokines and signs and symptoms of LNB were no longer observed. At study entry, most mediators were highly concentrated in CSF, the site of the infection. We tested whether those symptoms are caused by maladaptive immune responses by measuring 20 immune mediators in serum and cerebrospinal fluid (CSF) in 79 LNB patients followed for 1 year. Patients who have Lyme neuroborreliosis (LNB) might experience lingering symptoms that persist despite antibiotic drug therapy.

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